GtBP Family Proteins

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Abcam proteins for MSH6. Browse Sino Biological Assays. Genes that share domains with MSH6: view. Genes that share ontologies with MSH6: view.

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Genes that share phenotypes with MSH6: view. Cyagen custom transgenic mouse and rat models for MSH6. OriGene clones in human , mouse for MSH6. Search Addgene for plasmids for MSH6.

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Browse GeneCopoeia Cell Lines. Compartment Confidence nucleus 5 cytosol 4 golgi apparatus 4 plasma membrane 2 cytoskeleton 1 mitochondrion 1. Nucleoplasm 3 Golgi apparatus 2 Vesicles 2 See all subcellular structures.

Mismatch repair. Mismatch Repair in Eukaryotes. Mismatch Repair. DNA Damage. Colorectal cancer. Pathways in cancer.

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Platinum drug resistance. Genes that share pathways with MSH6: view. Colorectal cancer Mismatch repair Pathways in cancer Platinum drug resistance.

Activates: BLM. Genes that share compounds with MSH6: view. Browse Tocris compounds for MSH6. Browse compounds at ApexBio. This gene is overexpressed in Fetal ovary Show more. Protein tissue co-expression partners for MSH6 Gene. Nervous system 4.

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Germ Layers: ectoderm endoderm mesoderm. Systems: cardiovascular digestive endocrine immune integumentary nervous reproductive respiratory skeletal muscle skeleton urinary. Regions: Head and neck: brain cerebellum cerebrospinal fluid epiglottis eye eyelid face head larynx meninges neck skull vocal cord.

Thorax: breast esophagus trachea. Abdomen: adrenal gland biliary tract duodenum gallbladder intestine kidney large intestine liver pancreas small intestine stomach. Pelvis: anus ovary pelvis penis rectum ureter urethra urinary bladder uterus. Limb: arm upper limb. General: blood bone marrow red blood cell skin spinal cord white blood cell. Genes that share expression patterns with MSH6: view.

This gene was present in the common ancestor of eukaryotes. Orthologs for MSH6 Gene. Actinobacteria Mycobacterium tuberculosis African clawed frog Xenopus laevis Alicante grape Vitis vinifera alpha proteobacteria Wolbachia pipientis amoeba Dictyostelium discoideum Archea Pyrococcus horikoshii barley Hordeum vulgare beta proteobacteria Neisseria meningitidis Chromalveolata Phytophthora infestans common water flea Daphnia pulex corn Zea mays E. Genes that share paralogs with MSH6: view.

Variation tolerance for MSH6 Gene. Residual Variation Intolerance Score : 1. Gene Damage Index Score : 7. It is characterized by a familial predisposition to early-onset colorectal carcinoma CRC and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon.

Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. In many cases a protein family has a corresponding gene family , in which each gene encodes a corresponding protein with a relationship. The term protein family should not be confused with family as it is used in taxonomy.


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Proteins in a family descend from a common ancestor and typically have similar three-dimensional structures , functions, and significant sequence similarity. The most important of these is sequence similarity usually amino acid sequence since it is the strictest indicator of homology and therefore the clearest indicator of common ancestry.

There is a fairly well developed framework for evaluating the significance of similarity between a group of sequences using sequence alignment methods. Proteins that do not share a common ancestor are very unlikely to show statistically significant sequence similarity, making sequence alignment a powerful tool for identifying the members of protein families.

Families are sometimes grouped together into larger clades called superfamilies based on structural and mechanistic similarity, even if there is no identifiable sequence homology. Currently, over 60, protein families have been defined, [1] although ambiguity in the definition of protein family leads different researchers to wildly varying numbers.

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As with many biological terms, the use of protein family is somewhat context dependent; it may indicate large groups of proteins with the lowest possible level of detectable sequence similarity, or very narrow groups of proteins with almost identical sequence, function, and three-dimensional structure, or any kind of group in-between. To distinguish between these situations, the term protein superfamily is often used for distantly related proteins whose relatedness is not detectable by sequence similarity, but only from shared structural features.

A common usage is that superfamilies structural homology contain families sequence homology which contain sub-families. Hence a superfamily, such as the PA clan of proteases, has far lower sequence conservation than one of the families it contains, the C04 family. It is unlikely that an exact definition will be agreed and to it is up to the reader to discern exactly how these terms are being used in a particular context. The concept of protein family was conceived at a time when very few protein structures or sequences were known; at that time, primarily small, single-domain proteins such as myoglobin , hemoglobin , and cytochrome c were structurally understood.

Since that time, it was found that many proteins comprise multiple independent structural and functional units or domains. Due to evolutionary shuffling , different domains in a protein have evolved independently. This has led, in recent years, to a focus on families of protein domains. A number of online resources are devoted to identifying and cataloging such domains see list of links at the end of this article.

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  7. Regions of each protein have differing functional constraints features critical to the structure and function of the protein. For example, the active site of an enzyme requires certain amino acid residues to be precisely oriented in three dimensions. On the other hand, a protein—protein binding interface may consist of a large surface with constraints on the hydrophobicity or polarity of the amino acid residues. Functionally constrained regions of proteins evolve more slowly than unconstrained regions such as surface loops, giving rise to discernible blocks of conserved sequence when the sequences of a protein family are compared see multiple sequence alignment.

    These blocks are most commonly referred to as motifs , although many other terms are used blocks, signatures, fingerprints, etc. Again, a large number of online resources are devoted to identifying and cataloging protein motifs see list at end of article. According to current consensus, protein families arise in two ways.